New highly sensitivity assay used to measure cardiac troponin T concentration changes during a continuous 216-km marathon.
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چکیده
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منابع مشابه
Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays.
BACKGROUND Endurance exercise can increase cardiac troponin (cTn) concentrations as high as those seen in cases of minor myocardial infarction. The inability of most cTn assays to reliably quantify cTn at very low concentrations complicates a thorough data analysis, and the clinical implications of such increases remain unclear. The application of recently developed highly sensitive cTn immunoa...
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BACKGROUND In most patients with stable coronary artery disease, plasma cardiac troponin T levels are below the limit of detection for the conventional assay. The distribution and determinants of very low circulating troponin T levels, as well as their association with cardiovascular events, in such patients are unknown. METHODS We used a new, high-sensitivity assay to determine the concentra...
متن کاملImproved troponin T ELISA specific for cardiac troponin T isoform: assay development and analytical and clinical validation.
The first generation of troponin T ELISA (TnT 1) can yield false-positive results in patients with severe skeletal muscle injury. Therefore, a cardiac-specific second-generation troponin T ELISA (TnT 2) was developed, in which the cross-reactive antibody 1B10 has been replaced by a high-affinity cardiac-specific antibody M11.7. No cross-reactivity of TnT 2 was observed with purified skeletal mu...
متن کاملHigh-sensitivity cardiac troponin T release after a single bout of high-intensity interval exercise in experienced marathon runners
Objective The purpose of this study was to investigate the effects of a single bout of high-intensity interval exercise (HIIE) on high-sensitivity cardiac troponin T (hs-cTnT) release and to explore the potential influencing factors. Methods Twenty-one experienced marathon runners completed HIIE on treadmill. Each bout of HIIE included a hard run (15.8 ± 1.3 km·h-1) at 90% vVO2max for 2 min f...
متن کاملVariation of cardiac troponin I and T measured with sensitive assays in emergency department patients with noncardiac chest pain.
BACKGROUND New-generation high-sensitivity assays for cardiac troponin have lower detection limits and less imprecision than earlier assays. Reference 99th-percentile cutoff values for these new assays are also lower, leading to higher frequencies of positive test results. When cardiac troponin concentrations are minimally increased, serial testing allows discrimination of myocardial infarction...
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عنوان ژورنال:
- Clinical chemistry
دوره 55 3 شماره
صفحات -
تاریخ انتشار 2009